Objective: To discuss the case of a 62-year-old woman with prior history of breast cancer who later sought chiropractic care, and to present an overview of appropriate imaging procedures in such cases. Clinical features: The patient had a 6-month history of mild left-sided sacroiliac pain, which radiated into the left lateral thigh and leg. There was additional pain over the left upper ribs and left posterior arm, which had started insidiously. One year prior, she had undergone a lumpectomy. Current radiographs were negative for carcinoma. Intervention and outcome: Cautious spinal manipulation and soft tissue procedures were used to treat her sacroiliac joints. The thoracic pain was left untreated. The patient improved over the first 7 visits but had pain return after swimming. After ceasing therapy, she still suffered from similar pain. Conclusions: It is important to assess patients who present with new bone pain after they already have a history of breast malignancy. Chiropractic physicians should take appropriate diagnostic steps to rule out suspected malignancy when there is no plain film evidence and biopsy is negative.