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Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study


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Osteopathic Manipulative Treatment,Cranial and pediatric

J Alzheimers Dis. 2020;74(2):421-427.


Hope Tobey, Tyler Lucas, Soumen Paul, Stuart S Berr, Brittney Mehrkens, Per Gunnar Brolinson, Bradley G Klein, Blaise M Costa


Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer's disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if molecular mechanisms, which currently remain unclear, are elucidated. In the present pilot study, using transgenic rats, we have identified COM mediated changes in behavioral and biochemical parameters associated with AD phenotypes. We expect these changes may have functional implications that might account for improved clinical outcomes of COM treatment. Further investigations on COM will be helpful to establish an adjunct treatment for AD.

Publication Date: 

2020 Jan



Tobey, H., Lucas, T., Paul, S., Berr, SS., Mehrkens, B., Brolinson, GP., Klein, GB., Costa, MB. (2020) 'Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study ', J Alzheimers Dis. 2020;74(2):421-427.

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