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Role for Endocannabinoids in Spinal Manipulative Therapy Analgesia?

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Review

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Structural and chiropractic

Evid Based Complement Alternat Med.2019 Jul 15;2019:2878352.

Authors:

S M Onifer, R S Sozio, C R Long

Abstract.

Chronic pain is quite prevalent and causes significant disabilities and socioeconomic burdens. Spinal manipulative therapy and other manipulative therapies are used to manage chronic pain. There is a critical knowledge gap about mechanisms and sites of action in spinal manipulative therapy pain relief, especially the short-term analgesia that occurs following a treatment. Endocannabinoids are an activity-dependent neurotransmitter system that acts as a short-term synaptic circuit breaker. This review describes both clinical research and basic research evidence suggesting that endocannabinoids contribute to short-term manipulative therapy analgesia. Determining endocannabinoids involvement in spinal manipulative therapy will improve its clinical efficacy when results from basic science and clinical research are translated.

Publication Date: 

2019 Jul

OEID: 

5984

Onifer, MS., Sozio, SR., Long, RC. ( 201) 'Role for Endocannabinoids in Spinal Manipulative Therapy Analgesia?', Evid Based Complement Alternat Med.2019 Jul 15;2019:2878352.

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