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Fernández-pérez, MA., Peralta-ramírez, IM., Pilat, A., Moreno-lorenzo, C., Villaverde-gutiérrez, C., Arroyo-morales, M. (2013) 'Can myofascial techniques modify immunological parameters?', J Altern Complement Med.2013 Jan;19(1):24-8.

J Altern Complement Med.2013 Jan;19(1):24-8.

Can myofascial techniques modify immunological parameters?

Antonio Manuel Fernández-Pérez, Maria Isabel Peralta-Ramírez, Andrzej Pilat, Carmen Moreno-Lorenzo, Carmen Villaverde-Gutiérrez, Manuel Arroyo-Morales


Objectives: The objective was to determine the effect of myofascial techniques on the modulation of immunological variables. Design: Thirty-nine healthy male volunteers were randomly assigned to an experimental or control group. Interventions: The experimental group underwent three manual therapy modalities: suboccipital muscle release, so-called fourth intracranial ventricle compression, and deep cervical fascia release. The control group remained in a resting position for the same time period under the same environmental conditions. Outcome measures: Changes in counts of CD3, CD4, CD8, CD19, and natural killer (NK) cells (as immunological markers) between baseline and 20 minutes post-intervention. Results: Repeated-measures ANOVA revealed a significant time × groups interaction (F(1,35)=9.33; p=0.004) for CD19. There were no significant time × group interaction effects on CD3, CD4, CD8, or NK cell counts. Intrasubject analyses showed a higher CD19 count in the experimental group post-intervention versus baseline (t=-4.02; p=0.001), with no changes in the control group (t=0.526; p=0.608). Conclusion: A major immunological modulation, with an increased B lymphocyte count, was observed at 20 minutes after the application of craniocervical myofascial induction techniques.

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