Health and lifestyle early in life have profound impact on health and quality of life in later years. Common public health problems such as musculoskeletal disorders, cardiovascular disease, and depression tend to cluster in individuals, and this pattern is established early. At present, no health care profession has convincingly assumed the responsibility of spinal and musculoskeletal health for children. Considering the magnitude of the challenges ahead for both researchers and clinicians, this may be a good opportunity for doctors of chiropractic to take responsibility and engage in a determined effort to bring forward evidence-based strategies for prevention of spinal pain and other musculoskeletal problems. Chiropractors may play a significant role in finding and implementing evidence-based prevention and treatment strategies aimed at infants, children, and adolescents.