Manual medicine has been utilized in the treatment of patients for centuries and continues to be performed by osteopathic physicians, chiropractors, allopathic physicians with additional training, and some physical therapists in the United States. Practitioners of manual medicine have variable levels of training and utilize myriad techniquesto accomplish treatment. Manipulation has techniques for treatment of musculoskeletal dysfunctions throughout the body and can have a role in the treatment of many musculoskeletal ailments if the dysfunctions are the pain generators.